Pal et al. demonstrated that fetuin-A acts as an essential adaptor protein when free fatty acids (FFA) bind to Toll-like receptor-4 (TLR4) in both adipocytes and macrophages, signifying that FFA–fetuin-A–TLR4 ternary complex with intracellular activation of NF-κB can provoke systemic insulin resistance by enhancing proinflammatory cytokine secretion [4]. This evidence concerns the gene TLR4 and Insulin resistance.