Although it has been reported that miR-892b regulates the p19ARF/cyclin D1/CDK6 and Sp-1/MMP-9 signaling networks in bladder cancer and miR-3676 regulates T-cell leukemia/lymphoma 1 (TCL1) in chronic lymphocytic leukemia [42, 43], the role of the three miRNAs (miR-892b, miR-3135a, and miR-3676-3p) has never been reported in NPC. Here, SP1 is linked to B-cell chronic lymphocytic leukemia.