As a tumor suppressor21–23, endogenous Tyr33-phosphorylated WW domain-containing oxidoreductase (WWOX) binds the non-PEST area of inhibitor of nuclear factor κB (IκBα) and extracellular signal-regulated kinases (ERK) in MOLT-4, as determined by co-immunoprecipitation, yeast two-hybrid analysis, and end-point FRET microscopy13. This evidence concerns the gene WWOX and neoplasm.