This analysis identified tumour depth as the only significant independent predictor of low PO4-SMAD expression (Table 3, Wald (Chi-squared) = 7.447; p = 0.006; Exp(B) = 1.127, 95% C.I 1.034-1.227), indicating that for each unit increase in tumour depth (mm), the odds of a tumour expressing a histoscore (for both PO4-SMAD2 and PO4-SMAD3) at levels below the 25th percentile of the mean increased by 12.7% (Table 3, (1.127*100)-100) – with a 95% C.I of 3.4%–22.7%). The gene discussed is SMAD3; the disease is neoplasm.