Because after diagnosis, patients were all treated with CHOP chemotherapy, all together our data suggest that doxorubicin-containing chemotherapy could turn on miR-125b expression which might be linked to the recurrence of NPM-ALK(+) ALCL through BAK1 inhibition (Supplementary Figure 10), and therefore that alterations of miR-125b expression could predict therapeutic outcome. Here, ALK is linked to anaplastic large cell lymphoma.