ALK and lymphoma: MiR-125b was significantly downregulated in lymph nodes isolated from mice with NPM-ALK(+) lymphoma (ALK(+), N = 6 for each treatment) (Figure 1B and Supplementary Figure 1A), compared with lymph nodes isolated from either control normal age–matched wild type littermate mice (WT, N = 6); or healthy transgenic mice who had received either doxycycline (N = 6) (Figure 1B) or the ALK inhibitor, crizotinib (N = 4) [ALK(−) (Supplementary Figure 1A)].