Decitabine significantly decreased methylation levels at these sites in NPM-ALK(+) ALCL cells, with mean ratios reduced from 94.29% (untreated) to 54.24% (decitabine) for KARPAS-299 and 87% to 49.07% for COST (Supplementary Figure 2A). Here, ALK is linked to anaplastic large cell lymphoma.