ALK and anaplastic large cell lymphoma: Indeed, methylated miRNAs are already showing great potential as diagnostic and prognostic biomarkers in cancer therapy [17], for example our laboratories reported that the levels of two miRNAs, miR-29a and miR-150 were reduced in NPM-ALK(+) ALCL cell lines and biopsy specimens as a consequence of DNA hypermethylation [8, 18].