In several cancers, miR-125b induces chemoresistance to anthracyclins through suppression of various apoptotic modulators [26, 27, 35], thus in KARPAS-299 cells we evaluated whether miR-125b interacts with BAK1, P53, PUMA and MCL1 mRNAs which were identified as directly targeted by miR-125b [36, 37]. This evidence concerns the gene BBC3 and cancer.