MYCN and neuroblastoma: Hence, suppression of N-myc, which is a key prognostic factor in high-risk NB, is targeted by withanolides through modulation of multiple factors such as Akt, mTOR, GSK-3β, NF-κB etc. Many of the genes that are involved in the migration and metastasis of cancer cells like vascular endothelial growth factor and matric metallo proteinases are regulated by NF-κB.