Based on the results from our study, one possible mechanism through which withanolides prevent migration and potentiate apoptosis and cell cycle arrest in NB cells is through induction of oxidative stress coupled with a novel mechanism of HSP90 inhibition, which in NB targets key tumorigenic proteins such as Akt, mTOR, NF-κB and N-myc. Here, MTOR is linked to neuroblastoma.