Furthermore, increased expression of several growth factors such as tyrosine receptor kinase B (TrkB), insulin –like growth factor (IGF-1R) and epidermal growth factor (EGFR) that transmit their signals through PI3/Akt/mTOR pathway are known to be associated with drug resistance and increased expression of N-myc in NB [39]. This evidence concerns the gene EGFR and neuroblastoma.