AKT1 and neuroblastoma: Overall these results, along with the previous studies by Yco et al. [42] that showed inhibition of signal transducer and activator of transcription 3 (STAT3) by WA, indicate that withanolides have the ability to target both the upstream and downstream components of the PI3K/Akt/mTOR/MAPK pathway proteins that are implicated in the poor prognosis of NB.