Given that there is a large body of evidence that FGFs and their receptors are upregulated in PCa and that FGFR signaling is a potential drug target [26], we chose to examine the role of FGFs and FGFRs in the phenotypes observed in the TE, PTEN KD and PTEN KD/TE cell lines. Here, PTEN is linked to posterior cortical atrophy.