Meanwhile our data also revealed that the PERK inhibitor (GSK2606414) or PERK siRNA cannot reduce GANT-61-induced autophagy in the MYCN non-amplified NB cells (Figures 2A, 4B), as the MYCN non-amplified NB cells cannot activate the downstream UPR response to the same extent as PERK. This evidence concerns the gene EIF2AK3 and neuroblastoma.