However, in the MYCN non-amplified NB cells SK-N-AS, SK-N-SH and in the presence of tetracycline MYCN-(Tet+) NB cells the PERK siRNA could not induce a higher level of cell death than that obtained by the GANT-61 treatment alone (Figure 5A). This evidence concerns the gene EIF2AK3 and neuroblastoma.