Meanwhile our data also revealed that the PERK inhibitor (GSK2606414) or PERK siRNA cannot reduce GANT-61-induced autophagy in the MYCN non-amplified NB cells (Figures 2A, 4B), as the MYCN non-amplified NB cells cannot activate the downstream UPR response to the same extent as PERK. The gene discussed is MYCN; the disease is neuroblastoma.