These data provide strong evidence that blocking the RhoA/Rho-kinase pathway prevents AGEs-induced EMT in HPMCs and suggest, in line with a study by Zhang et al. showing a role for RhoA/Rho-kinase signaling in TGF-β1-induced EMT in rat PMCs [35], the potential therapeutic value of RhoA-kinase inhibitors in the treatment of PD-related PF. This evidence concerns the gene RHOA and pemphigus foliaceus.