HMGA1 and breast cancer: Consistent with the findings in matrigel and ALI cultures, MKI67 expression in BC is down-regulated 24, 48 and 72 hr after HMGA1 siRNA transfection, suggesting lower proliferation capacity in HMGA1-silenced BC (siHMGA1 vs siControl, all p < 0.05; Supplementary Figure 3A).