HMGA1 and breast cancer: Based on the foregoing data demonstrating that reduced expression of HMGA1 inhibits normal differentiation of airway epithelium BC, and given prior observations that dysregulation of BC function can lead to production of cells with a squamous character, we hypothesized that low expression of HMGA1 would correlate with the expression of common markers of squamous epithelial cells [51, 60, 61].