PTGS2 and breast cancer: Interestingly, the BC with silenced HMGA1 exhibited up-regulated expression, not only of the squamous-related genes KRT6B, IVL and SFN, but also EMT-related genes VIM, COL1A1, and MMP2, and inflammation-related genes IL1A, IL1B, IL6, IL8 and PTGS2 (Figure 6A, siHMGA1 vs siControl all p < 0.05) [61, 62].