Our studies show that in vitro delivery of purified 1C11 anti-C-terminus Shh antibodies decreased NSCLC A549 tumor cell proliferation as evidenced by a modest reduction of cell viability compared to treatment with control antibody, and that sub-clone 2G4 showed a marginally stronger anti-proliferative capacity than 2D9 (Figure 4B). This evidence concerns the gene SHH and neoplasm.