Based on the PROSPECT and TCGA analyses, we chose to further explore gene expression and drug sensitivity data on TrkB, Chk2, and NCOA3, as they met the following criteria: 1) higher expression in SCC; 2) high levels of associations with histology (SCC subtype) in both clinical datasets (when available); 3) directly targetable, but with limited clinical evidence pertaining to the appropriate targeted agent; and 4) prior evidence demonstrating that the targeting the protein or pathway could affect outcome in NSCLC. The gene discussed is CHEK2; the disease is non-small cell lung carcinoma.