Whereas expression of TRAIL-R1 could not be detected in any of the NPC cell lines studied, we were able to demonstrate high expression of TRAIL-R2 in five out of six NPC cell lines; only weak expression of TRAIL-R2 was observed in cell line C666-1 and C17-PDX cells. The gene discussed is TNFRSF10A; the disease is nasopharyngeal carcinoma.