There were significant differences in etiology (HBV/HCV/others = 6/36/37 vs. 17/92/19, P <.0001), BMI (25.3 vs. 21.7 kg/m2, P <.0001), L3 SMI (47.0 vs. 42.7 cm2/m2, P <.0001), VFMI (66.5 vs. 24.4 cm2/m2, P <.0001), SFMI (46.3 vs. 31.9 cm2/m2, P <.0001), platelet count (14.8 vs. 12.1 × 104/mL, P = 0.003), hemoglobin A1c (6.5 vs. 5.9%, P <.0001), triglycerides (117.4 vs. 91.6 mg/dL, P = 0.004), and leptin (8.2 vs. 5.1 ng/mL, P = 0.043) between the groups, and most of these differences were associated with obesity and metabolic disorders. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.