To investigate the effect of LINC01510 on CRC cell proliferation, first, pCDNA3.1-LINC01510 for LINC01510 overexpression and sh-LINC01510 for LINC01510 silencing were constructed and transfected in LoVo and SW620 cells, respectively. The gene discussed is COMETT; the disease is colorectal carcinoma.