The expression of ER stress markers, such as ATF6 (activating transcription factor 6), GPR78 (glucose-regulated protein 78), PERK (Protein kinase RNA-like endoplasmic reticulum kinase), EIF2 (eukaryotic initiation factor 2), and IRE1 (Inositol-requiring enzyme 1) are altered in AD patient samples24–26. The gene discussed is ERN1; the disease is Alzheimer disease.