CTNNB1 and cancer: In addition, height is a highly polygenic trait, withmany biological pathways implicated in determining variation in height (e.g.,skeletal growth, FGF signalling, WNT signalling, regulation of beta-catenin, mTORsignalling).22 Understanding the causal biological pathwaysbetween genetic variants that contribute to height, and subsequently cancer risk,requires functional annotation of variants, along with larger sample sizes toachieve sufficient statistical power for these analyses.