SMOX and infection: Here, we demonstrate (Fig. 3) that CYS could potentiate the activity of the fluoroquinolone ciprofloxacin in the neutropenic mouse thigh model of infection against the MDR P. aeruginosa Liverpool epidemic strain 431 (LES431), which, unlike PAO1, has a resistant MIC of 4 μg/ml (39) as defined by CLSI and EUCAST clinical breakpoints.