These methods were coupled to functional assays including assessments of antibody‐dependent cellular cytotoxicity (ADCC), complement deposition (ADCD), neutrophil phagocytosis (ADNP), and natural killer (NK) cell activation (NKA) as measured by CD107a, IFNγ, and MIP1β expression—antiviral activities that have correlated with protection from infection in animal models (Barouch et al, 2013, 2015; Fouts et al, 2015; Bradley et al, 2017). This evidence concerns the gene IFNG and infection.