TF and Huntington disease: However, when we considered the broader set of 209 TF‐target gene modules from the primary mouse RNA‐seq dataset, we found significant overlap for TF‐target gene modules that were downregulated both in HD and in HD mouse models (28 shared TF‐target gene modules; odds ratio = 3.6, P = 5.0e‐5; Appendix Fig S6D) and for TF‐target gene modules that were upregulated both in HD and in HD mouse models (26 shared TF‐target gene modules; odds ratio = 1.8, P = 0.02; Appendix Fig S6E).