Notably, the predicted target genes for several TFs whose functions in HD have been studied by other investigators—for example, REST (Zuccato et al, 2003), SREBF2 (Valenza et al, 2005), and FOXP1 (Tang et al, 2012)—were overrepresented for differentially expressed genes in our model, but only at later time points or more weakly than our top 48 core regulator TFs. This evidence concerns the gene SREBF2 and Huntington disease.