Others have shown that mRNA expression of ENG is increased in the placenta, maternal blood (cellular and non-cellular components), and maternal microvascular endothelial cells [13], [14], [15], [16], [17], [18], [19], [20] while levels of sENG protein in the maternal circulation are elevated weeks to months before overt disease in women with preeclampsia [21], [22]. The gene discussed is ENG; the disease is preeclampsia.