As research on the PD-1/PD-L1 axis continues, a variety of molecules are found to have a role in the regulation of PD-L1 expression, such as Sigma1 inhibitor IPAG [126], serine protease inhibitor nafamostat mesilate [127] or VEGFR-2 inhibitor Apatinib [128], and there is a rationale for investigating their application in MM. The gene discussed is PDCD1; the disease is Miyoshi myopathy.