Similarly, Nabet et al. [3] discovered that breast cancer cells can stimulate NOTCH-MYC signaling in activated fibroblasts within the tumor microenvironment, producing exosomes containing unshielded (activated) RN7SL1, an endogenous RNA that is normally shielded (deactivated) by RNA-binding proteins. Here, RN7SL1 is linked to neoplasm.