HRAS and acute lymphoblastic leukemia: Because PTX008 interferes with Galectin-1 dimerization [12], and Galectin-1 dimers promote H-Ras nanoclustering in epithelial cells [31–33] we also analyzed Galectin-1, pSrc and pErk1/2 protein levels in lysates of BP-ALL cells treated with PTX008.