Interestingly, stimulation of US7 BP-ALL cells by the addition of exogenous Galectin-3 induced an increase in Galectin-1 mRNA expression (Fig. 1c, compare US7 control GST to GST-Galectin-3), indicating that in some ALLs, its levels are likely to be regulated by external factors. This evidence concerns the gene LGALS1 and acute lymphoblastic leukemia.