The results also suggested that preoperative CA125 level in optimal debulking group was significantly lower than that of suboptimal debulking group (p = 0.043), suggesting that preoperative CA125 levels significantly correlated with the size of residual tumor, thus can be used to evaluate the effect of cytoreductive surgery, while GDF15 has no such clinical value (Table 2). The gene discussed is MUC16; the disease is neoplasm.