The event-based model reveals a distinct sequence of biomarker abnormality in dominantly-inherited Alzheimer’s disease: regional (cortical then striatal) amyloid deposition on PiB-PET scans; CSF measures of neuronal injury (total tau), neurofibrillary tangles (phosphorylated tau), and amyloid plaques (amyloid-β42 and amyloid-β40/amyloid-β42 ratio); MRI measures of volume loss in the putamen and nucleus accumbens. Here, PNRC1 is linked to early-onset autosomal dominant Alzheimer disease.