METAP2 and Familial prostate cancer: When analyzing pathways associated with colorectal (Fig 4A) and prostate cancers (Fig 4B), we observed that miRNAs targeting both NMT1/2 and MetAP2 genes also regulate the expression of key genes involved in these pathways, including AKT1, GSK3B, BRAF, MAPK and many others (Fig 4).