Along with suppression of tumor growth, there was also a significant decrease in Ki67-positive cells (consistent with decrease in cell proliferation) and increase in cleaved caspase-3 levels in tumor tissues when treated with combination of auranofin and vorinostat or rapamycin, further supporting the synergism between auranofin and vorinostat or rapamycin. The gene discussed is MKI67; the disease is neoplasm.