The same CCHFV serum panel which had been analyzed with the BLACKBOX CCHFV IgM ELISA and the BLACKBOX CCHFV IgG ELISA (15 serum pairs from CCHF patients, 12 sera from convalescent patients collected approximately one year after the infection), 15 a priori CCHFV-IgM/IgG negative control sera and 98 CCHFV IgM/IgG IIFT negative sera from healthy Kosovar blood donors were tested with both the VectoCrimean-CHF-IgM ELISA (Fig 3C, Fig 4B, panel C in S1 Fig, S2 Fig, S3 Fig) and the VectoCrimean-CHF-IgG ELISA (Fig 3D, Fig 4B, panel D in S1 Fig, S2 Fig, S3 Fig). This evidence concerns the gene CD40LG and infection.