In agreement with the hypothesis of impaired adipogenesis induced by LMNA mutations, we and others reported that expression of adipogenic genes was altered in adipose tissue from patients with FPLD2, both at thigh [57,58] and cervical levels [59], with a decreased expression of the master adipogenic factor PPAR-gamma. Here, LMNA is linked to familial partial lipodystrophy, Dunnigan type.