IGHE and allergic disease: These responses include B cell differentiation, the production of antigen‐specific IgE and secretion of a range of cytokines and chemokines.20 The IgE‐triggered release of chemical mediators from granulocytes ultimately results in systemic symptoms that characterize an allergic reaction, including urticaria and anaphylaxis.20 These reactions are maintained by late‐phase chemokine and pro‐inflammatory cytokine secretion, and subsequent recruitment of additional leucocytes.20