Previous studies have shown that closed‐loop intervention improves glycaemic control in type 1 diabetes through the system's ability to adjust insulin delivery in response to varying insulin requirements.14 Figure 2 demonstrates this paradigm; comparing the mean insulin delivery at approximately 0.8 U/h observed even during imminent onset of hypoglycaemia, closed‐loop intervention reduced insulin delivery from −60 to 80 minutes relative to onset of overnight hypoglycaemia and from −60 to 50 minutes relative to daytime hypoglycaemia. The gene discussed is INS; the disease is type 1 diabetes mellitus.