Regarding the parameters related to the inflammatory process, RT-PCR and Western blot results showed a significant increase of iNOS transcription (P < 0.001) (Figures 4(a) and 4(d)) and expression (P < 0.05) (Figures 4(f) and 4(i)) in the FC of placebo-treated 3×Tg-AD mice in comparison with placebo-treated non-Tg animals. Here, NOS2 is linked to Alzheimer disease.