Regarding antiretrovirals, HAART treatment, especially protease inhibitor containing regimens, has been associated with thrombotic events, possibly because of the interference with the regulation of thrombotic proteins leading to increased fibrinogen, D dimer, plasminogen activator inhibitor 1 or protein S deficiency [9]. This evidence concerns the gene PROS1 and hyperinsulinemic hypoglycemia, familial, 4.