GLS and chondrosarcoma: Inhibition of glutaminase using CB-839 in ten chondrosarcoma cell lines revealed that HT1080 (IDH1R132C), SW1353 (IDH2R172S) and, to a lesser extent, JJ012 (IDH1R132G), were very sensitive for glutaminase inhibition, with IC50 values below 5 μM (Fig. 3b, Table 1).