Our findings were similar with the opinions of other scholars, namely NF-κB plays a negative regulatory role in the process of TRAIL apoptotic signalling.27 Furthermore, after drug-resistant gastric cancer cells were transfected with LV-METase, NF-κB pathway was inactivated and LV-METase inhibited NF-κB activity, ultimately alleviating Cisplatin-resistant and promoting Cisplatin-induced cell death. The gene discussed is TNFSF10; the disease is gastric cancer.