FCGR2A and neoplasm: This was only observed within the tumor microenvironment, demonstrating that, in the context of human FcγR-human IgG interactions in vivo, depletion of tumor-infiltrating Treg cells is a major contributor to the shift in this ratio, which has previously been associated with therapeutic responses in mouse and humans (Hodi et al., 2008, Quezada et al., 2006).