To address this key question, and in the absence of publicly available RNA‐seq data on HD and CP‐CML CD34+CD15− cells, we evaluated the transcriptional status of PB CD34+ cells to identify candidate genes the expression of which could be affected by aberrant DNA methylation of their promoter in CP‐CML CD34+CD15− cells. The gene discussed is CD34; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.