In immature CP‐CML CD34+CD15− cells, we identified about two times more hypomethylated than hypermethylated DMRs (742 vs 400), suggesting that the trend toward hypomethylation observed during normal differentiation into the myeloid lineage (Farlik et al., 2016) is accentuated during malignant transformation. This evidence concerns the gene CD34 and chronic myelogenous leukemia, BCR-ABL1 positive.