IGHE and asthma: Given intranasally to mice, the major secreted proteinases from the fungus, Aspergillus oryzae are alone sufficient to induce major features of asthma, including T helper type 2 (TH2) cell recruitment to lungs, airway hyperresponsiveness, goblet cell metaplasia, airway eosinophilia, and elevated serum IgE in a manner that requires intact proteinase activity 13.