The non‐coding RNA linc‐Adamts‐5, which blocked Adamts‐5 expression, was protective against IDD.52 Adamts‐5 siRNA could also effectively suppress Adamts‐5 production in the nucleus pulposus, improving both imaging and histologic grade in a rabbit needle‐puncture model.53 We demonstrated that TBHP significantly increases MMP13 and Adamts‐5 expression. The gene discussed is MMP13; the disease is intervertebral disk degenerative disorder.