MTOR and muscular dystrophy: In support of our model, transcriptomics data from muscle tissue of an individual with muscular dystrophy expressing Lamin A/C G449V (analogous to Drosophila G489V) showed (1) upregulation of transcripts from Nrf2 target genes, (2) upregulation of genes encoding subunits of the mTOR complex, and (3) downregulation of AMPK (unpublished data), further demonstrating relevance of the Drosophila model for providing insights on human pathology.