CYP2D6 and myocardial infarction: This is important because individuals with different CYP2D6 genotypes may have a different response toward the interaction.39 Goryachkina et al reported that among 17 patients with acute myocardial infarction treated with the combination of metoprolol‐paroxetine, there were 2 patients experiencing dose adjustments due to hypotension and bradycardia.