Again though, this might be due to increased proportions of plasmablasts in peripheral blood in SLE as naïve B‐cell BCRs tend to have longer CDR3 lengths than antigen‐experienced B‐cells.49 Some of the difficulties interpreting such data could be resolved through isotype‐specific BCR sequencing or through investigation of cell‐sorted B‐cell populations, including naïve, memory and plasma cells. The gene discussed is BCR; the disease is systemic lupus erythematosus.