In these studies, the outcome of relevant factors was very different with the Nakayama study giving symptoms, perennial allergy, disease severity, asthma/eosinophilic mucin, and eosinophilic inflammation as important factors and Soler stating that clustering was mainly determined by age, severity of patient reported outcome measures, depression, and fibromyalgia and indicating that traditional clinical measures, including polyp/atopic status, prior surgery, smell, and asthma did not vary among clusters [21, 22]. Here, MUC5AC is linked to asthma.