IL5 and chronic rhinosinusitis without nasal polyps: The first group of IL-5-negative clusters clinically resembled a predominant chronic rhinosinusitis without nasal polyp (CRSsNP) phenotype without increased asthma prevalence, the 4 clusters in the middle showed a mixed CRSsNP/CRSwNP phenotype and increased asthma phenotype and the IL-5-high clusters an almost exclusive nasal polyp phenotype with strongly increased asthma prevalence [26].