CASP8 and metabolic dysfunction-associated steatohepatitis: Interestingly, although alcoholic liver diseases and NASH share similar clinical and pathological manifestations, caspase 8 inhibition does not seem to protect mice from ethanol-induced apoptosis and actually enhances caspase 9 (CASP9)-dependent intrinsic (mitochondrial) cell death by inducing release of cytochrome c [38].