Although the CFLAR/ASK-1/JNK1 pathway may contribute to inflammation and fibrosis during NASH, the ASK-1-related pathway may be dispensable for hepatocyte cell death, as ASK-1 inhibition has been shown to have no effect on palmitic acid-induced JNK1 activation and apoptosis [68]. Here, CFLAR is linked to metabolic dysfunction-associated steatohepatitis.