A significantly higher serum CRP concentration (Fig. 1) was found in the decompensated stage of heart failure (ISACHC III; median 15.5 mg/L, interquartile range 10.0–34.8 mg/L) compared with healthy dogs (P = 0.001; median 10.0 mg/L, interquartile range 10.0–10.0 mg/L) and with patients in ISACHC group II (P < 0.001; median 10.0 mg/L, interquartile range 10.0–10.0 mg/L) and ISACHC group I (P = 0.011; median 10.0 mg/L, interquartile range 10.0–10.0 mg/L). This evidence concerns the gene CRP and heart failure.