Though several factors, such as p53 alternation, dysregulation of miRNAs, overexpression of Bcl‐2, NF‐κB, or COX2 4, 7, 8, 9, 10, are reportedly related to the radioresistance of laryngeal cancer, the detailed mechanism by which the radioresistance of laryngeal cancer is induced still remains unclear. The gene discussed is TP53; the disease is laryngeal carcinoma.