NFKB1 and breast cancer: 15 demonstrated that NKILA can combine with NF‐κB: IκB complex, thus suppressing the cell migration and invasion of breast cancer, inhibiting IKK‐induced IκB phosphorylation and finally blocking the activation of NF‐κB signaling. Similarly, NKILA plays a crucial role in suppressing tongue squamous cell carcinoma cell migration and invasion through hindering IκB phosphorylation, NF‐κB activation, and the following EMT process 18.