15 demonstrated that NKILA can combine with NF‐κB: IκB complex, thus suppressing the cell migration and invasion of breast cancer, inhibiting IKK‐induced IκB phosphorylation and finally blocking the activation of NF‐κB signaling. Similarly, NKILA plays a crucial role in suppressing tongue squamous cell carcinoma cell migration and invasion through hindering IκB phosphorylation, NF‐κB activation, and the following EMT process 18. Here, NFKB1 is linked to tongue squamous cell carcinoma.