In addition to affecting sRAGE levels, AGE accumulation in adipocytes dysregulates production of adipokines, such as adiponectin, leptin, monocyte chemoattractant protein 1 (MCP‐1), and plasminogen activator inhibitor type I (PAI‐1), through binding to RAGE 16, 17, which may affect pancreatic cancer risk. This evidence concerns the gene ADIPOQ and familial pancreatic carcinoma.