Our study advanced knowledge on dysregulation of adipokines in pancreatic cancer in the context of the sRAGE which showed that sRAGE‐adiponectin and MCP‐PAI1 act differently in pancreatic cancer carcinogenesis, while leptin is involved in both RAGE‐ and MCP1‐related mechanisms. Here, SERPINE1 is linked to familial pancreatic carcinoma.