In a sensitivity analysis where we included controls who later developed cancers of breast, colon–rectum, and lung during follow‐up and their matched pancreatic cancer cases, the association between sRAGE and pancreatic cancer was only moderately attenuated and became nonsignificant, while risk estimates for PAI1 were attenuated more than 10%. This evidence concerns the gene SERPINE1 and familial pancreatic carcinoma.