However, in OUMS27shPPAR and SW1353shPPAR cells, the downregulation of MMP2 activities by zaltoprofen was inhibited by PPARγ silencing (Fig. 4C), thus, suggesting that a zaltoprofen‐induced PPARγ activation could reduce MMP2 activities in chondrosarcoma cells. This evidence concerns the gene PPARG and chondrosarcoma.