TM6SF2 and metabolic dysfunction-associated steatotic liver disease: Likewise, the missense p.Glu167Lys (rs58542926) variant located in TM6SF2 (transmembrane 6 superfamily member 2) gene, while protecting against cardiovascular disease (CVD)4,5, has been associated with a modest risk of liver fat accumulation (OR ~2.13)5, NAFLD, and the NAFLD severity6–11.