MBOAT7 and metabolic dysfunction-associated steatotic liver disease: Interestingly, a missense (p.Gly17Glu, rs641738 C/T) variant located in exon 1 of TMC4 (transmembrane channel-like 4) gene and intergenic downstream of MBOAT7 gene has been associated with a modest risk of developing NAFLD (OR ~1.37), NASH, and fibrosis12.